Endocrine Abstracts

A 68 year old gentleman referred to endocrinology clinic with a few years history of erectile dysfunction (ED), which manifested as reduced libido and partial erections. Investigations revealed primary hypogonadism with a low morning serum Testosterone of 4.8 (Ref: 7.9-31 nmol/l), raised FSH at 47 (Ref:1.5-12.4 iu/l) LH at 36.8 (Ref: 1.7-8.6iu/l) and normal thyroid function tests (TFTs). The patient declined testosterone replacement therapy following a discussion of pros and c...

Case history: A 32 year old female was admitted for an elective gynaecological procedure LLETZ (large loop excision of the transformation zone) under general anaesthesia as per patient”s request. An uncomplicated LLETZ procedure was performed. Post operatively, patient was found to be tachycardiac and had severe palpitations with nausea. She then reported that she had recently lost a significant amount of weight, had been suffering with anxiety, palpitations, and tremors ...

Introduction: Lithium is a common pharmacological intervention for the treatment of bipolar affective disorder and is advocated by clinical practice guidelines (NICE 2021). Blood test monitoring is essential for management of lithium treatment and UK NICE guidance recommends 6-monthly serum testing of thyroid function. We here examine conformity to guidance and the consequences of monitoring outside these intervals.Methods: We extracted serum lithium/thy...

The heart not only has a mechanical function of pumping blood through vessels but also acts as an endocrine gland. In its endocrine function, the heart releases atrial natriuretic peptide (ANP), a hormone of a large family of natriuretic peptides. ANP is secreted from cardiac atria as an inactive preprohormone. In post-translational modification, 25-amino acid signal sequence is cleaved from preprohormone to produce proANP of 126-amino acid, which is the major form of ANP stor...

Hypertension is associated with vascular changes characterized by endothelial dysfunction, increased vascular contraction, and arterial remodelling. Vascular smooth muscle (VSM) cells, which constitute bulk of vascular wall, are critically involved in these processes through their highly plastic and dynamic features and ability to undergo phenotypic differentiation. Stimulation of VSM cells by pro-hypertensive neurohumoral stimuli such as acetylcholine and norepinephrine, and ...

Cardiovascular dysfunction (CVD) is a well recognized complication in patients with hyperthyroidism and is the major cause of mortality. To date there has been no studies which had clearly evaluated the CVD and its recovery pattern between patients with Graves and Toxic multi nodular goitre(TMNG). Hence we intended to compare treatment outcomes in patients with Graves and TMNG. Patients with hyperthyroidism were grouped into, Group 1 [n=133, age<6...

Case presentation: A 66 year old male presented to the clinical physiology department for a routine ECHO. He was found to be hemodynamically unstable with fast Atrial fibrillation and was referred to ED for immediate management. He was subsequently admitted in CCU under Cardiology. He presented with a 3 month history of shortness of breath, palpitations, persistent tremors, unintentional weight loss and generalised fatigue. No previous thyroid problems. He had a longstanding h...

Introduction: Hypophosphatasia (HPP) is a very rare systemic musculoskeletal disease characterised by low tissue non-specific alkaline phosphatase (ALP). The prevalence of HPP and its associated morbidity in an adult setting is unclear.Methods: A search for serum ALP results less than 36 IU/l within NHS Greater Glasgow and Clyde between 2017 and 2018 revealed 16 280 results. A further search for patients with two ALP <36 separated by 30 days or more ...

Secondary hormonal deficiency (SHD) in sellar masses (SM) is thought to be partly due to compression of the portal vessels by the enlarging tumour restricting the blood supply to the normal pituitary tissue. However, to date no study has looked at the patterns of SHD in various types of SM and assessed if SHD is related solely to the size of SM or is associated with the underlying pathology. We assessed 914 patients with SM enrolled in our comprehensive pituitary registry sinc...

Patients with sellar masses (SM) undergoing transsphenoidal surgery (TSS) have a significant risk of transient or permanent endocrine dysfunction; therefore, in-hospital endocrinology consultation (IHEC) is recommended for these patients. However, routine assessment of all TSS patients by a specialized team is not feasible outside select centers. We developed an IHEC guide for TSS patients in December 2015 to identify those patients who would require perioperative IHEC. We con...